Naloxone decreases tolerance to hypotensive, hypovolemic stress healthy humans.

abstract

• OBJECTIVE: In animal studies, naloxone, an opioid receptor antagonist, improves tolerance to hemorrhagic shock. The purpose of this study was to determine whether naloxone would augment tolerance to hypotensive hypovolemic stress (lower body negative pressure [LBNP]) in healthy human males. DESIGN: This study was a repeated measures design. SETTING: The experiments were conducted in a laboratory setting. SUBJECTS: Eight healthy male subjects were tested. The subjects' ages were 30 +/- 4.0 yrs, height = 177 +/- 7.0 cm, and weight = 75.5 +/- 3.5 kg (mean +/- SEM). INTERVENTIONS: Subjects underwent two LBNP exposures terminated by the onset of vasodepression. At each of the exposures, using a double-blind procedure, the subjects received an intravenous injection of either saline placebo or naloxone in a dosage totaling 0.4 mg/kg.

published proceedings

• Crit Care Med

author list (cited authors)

• Lightfoot, J. T., Katz, L., & DeBate, K.

citation count

• 8

complete list of authors

• Lightfoot, JT||Katz, L||DeBate, K

publication date

• January 2000

publisher

• Wolters Kluwer  Publisher

published in

• Critical Care Medicine  Journal

keywords

• Adult
• Analysis Of Variance
• Blood Pressure
• Double-Blind Method
• Forearm
• Hemodynamics
• Humans
• Hypovolemia
• Lower Body Negative Pressure
• Male
• Naloxone
• Narcotic Antagonists
• Prospective Studies
• Regional Blood Flow
• Shock, Hemorrhagic

PubMed Central ID

• 10752815

Digital Object Identifier (DOI)

• 10.1097/00003246-200003000-00014

start page

• 684

end page

• 691

volume

• 28

issue

• 3

URL

• http://dx.doi.org/10.1097/00003246-200003000-00014