OBJECTIVE: Study of radiographic features of maxillary sinusitis of odontogenic origin as visualized on 3-dimensional advanced imaging is essential for prompt diagnosis and appropriate management. This study attempted to describe and delineate radiographic characteristics of this condition. STUDY DESIGN: Three cases of failed endodontic therapy presenting with confounding clinical signs and symptoms were subjected to 3-dimensional imaging with cone-beam volumetric computerized tomography (CBVCT) to evaluate changes in the maxillary sinuses. RESULTS: CBVCT showed varying involvement of the ipsilateral maxillary sinus in all 3 cases. The presentation varied from presence of intrasinus fluid to reactionary osseous response within the sinus. CONCLUSIONS: CBVCT as a diagnostic aid to evaluate the involvement of the maxillary sinuses in cases of endodontic treatment failure seems to assist with formulation of a definitive diagnosis. Appropriate interventions may be instituted, including an otolaryngology consultation.