Pharmacokinetics of a single dose of oclacitinib maleate asatop dress in adult horses. Academic Article

abstract

• The objective of this study was to determine the pharmacokinetic parameters of oclacitinib maleate as a top dress given to adult horses. Six adult horses with a mean weight of 528kg were administered a single dose of 0.5mg/kg oclacitinib maleate. Blood was collected prior to drug administration and at 15min, 30min, 45min, 1, 2, 4, 6, 8, 12, 24, 48, and 72h after treatment. Oclacitinib maleate plasma concentrations were measured by liquid chromatography/mass spectrometry. Pharmacokinetic parameters were found best to fit a one-compartment model. Mean Cmax was 486ng/ml (range 423-549ng/ml), and Tmax was estimated to be 1.7h (range 0.3-3.1h). The estimated T1/2 was 7.5-8h.

authors

• Fajt, Virginia

published proceedings

• J Vet Pharmacol Ther

altmetric score

• 0.25

author list (cited authors)

• Hunyadi, L., Datta, P., Rewers-Felkins, K., Sundman, E., Hale, T., Fajt, V., & Wagner, S.

citation count

• 0

complete list of authors

• Hunyadi, Laszlo||Datta, Palika||Rewers-Felkins, Kathleen||Sundman, Emily||Hale, Thomas||Fajt, Virginia||Wagner, Sarah

publication date

• January 2022

publisher

• Wiley  Publisher

published in

• Journal of Veterinary Pharmacology and Therapeutics  Journal

keywords

• Administration, Oral
• Allergic Dermatitis
• Animals
• Apoquel
• Area Under Curve
• Chromatography, Liquid
• Horses
• Maleates
• Oclacitinib
• Pharmacokinetics
• Pyrimidines
• Sulfonamides

PubMed Central ID

• 35098559

Digital Object Identifier (DOI)

• 10.1111/jvp.13043

start page

• 320

end page

• 324

volume

• 45

issue

• 3

URL

• http://dx.doi.org/10.1111/jvp.13043