CSCD2: an integrated interactional database of cancer-specific circular RNAs. uri icon

abstract

  • The significant function of circRNAs in cancer was recognized in recent work, so a well-organized resource is required for characterizing the interactions between circRNAs and other functional molecules (such as microRNA and RNA-binding protein) in cancer. We previously developed cancer-specific circRNA database (CSCD), a comprehensive database for cancer-specific circRNAs, which is widely used in circRNA research. Here, we updated CSCD to CSCD2 (http://geneyun.net/CSCD2 or http://gb.whu.edu.cn/CSCD2), which includes significantly more cancer-specific circRNAs identified from a large number of human cancer and normal tissues/cell lines. CSCD2 contains >1000 samples (825 tissues and 288 cell lines) and identifies a large number of circRNAs: 1013461 cancer-specific circRNAs, 1533704 circRNAs from only normal samples and 354422 circRNAs from both cancer and normal samples. In addition, CSCD2 predicts potential miRNA-circRNA and RBP-circRNA interactions using binding motifs from >200 RBPs and 2000 microRNAs. Furthermore, the potential full-length and open reading frame sequence of these circRNAs were also predicted. Collectively, CSCD2 provides a significantly enhanced resource for exploring the function and regulation of circRNAs in cancer.

author list (cited authors)

  • Feng, J., Chen, W., Dong, X., Wang, J., Mei, X., Deng, J., ... He, C.

complete list of authors

  • Feng, Jing||Chen, Wenbo||Dong, Xin||Wang, Jun||Mei, Xiangfei||Deng, Jin||Yang, Siqi||Zhuo, Chenjian||Huang, Xiaoyu||Shao, Lin||Zhang, Rongyu||Guo, Jing||Ma, Ronghui||Liu, Juan||Li, Feng||Wu, Ying||Han, Leng||He, Chunjiang