Defining a master curve of abdominal aortic aneurysm growth and its potential utility of clinical management. Academic Article uri icon


  • OBJECTIVE: The maximum diameter measurement of an abdominal aortic aneurysm (AAA), which depends on orthogonal and axial cross-sections or maximally inscribed spheres within the AAA, plays a significant role in the clinical decision making process. This study aims to build a total of 21 morphological parameters from longitudinal CT scans and analyze their correlations. Furthermore, this work explores the existence of a "master curve" of AAA growth, and tests which parameters serve to enhance its predictability for clinical use. METHODS: 106 CT scan images from 25 Korean AAA patients were retrospectively obtained. We subsequently computed morphological parameters, growth rates, and pair-wise correlations, and attempted to enhance the predictability of the growth for high-risk aneurysms using non-linear curve fitting and least-square minimization. RESULTS: An exponential AAA growth model was fitted to the maximum spherical diameter, as the best representative of the growth among all parameters (r-square: 0.94) and correctly predicted to 15 of 16 validation scans based on a 95% confidence interval. AAA volume expansion rates were highly correlated (r=0.75) with thrombus accumulation rates. CONCLUSIONS: The exponential growth model using spherical diameter provides useful information about progression of aneurysm size and enables AAA growth rate extrapolation during a given surveillance period.

published proceedings

  • Comput Methods Programs Biomed

author list (cited authors)

  • Akkoyun, E., Gharahi, H., Kwon, S. T., Zambrano, B. A., Rao, A., Acar, A. C., Lee, W., & Baek, S.

citation count

  • 3

complete list of authors

  • Akkoyun, Emrah||Gharahi, Hamidreza||Kwon, Sebastian T||Zambrano, Byron A||Rao, Akshay||Acar, Aybar C||Lee, Whal||Baek, Seungik

publication date

  • January 2021