Association of vortical structures and hemodynamic parameters for regional thrombus accumulation in abdominal aortic aneurysms Academic Article uri icon


  • The intraluminal thrombus (ILT) has been shown to negatively impact the progression of the abdominal aortic aneurysms (AAAs). The formation of this thrombus layer has been connected to the local flow environment within AAAs, but the specific mechanisms leading to thrombus formation are still not fully understood. Our study investigated the association between vortical structures, near-wall hemodynamic metrics (e.g., time averaged wall shear stress (TAWSS) and oscillatory shear index (OSI)), and ILT accumulation in a longitudinal cohort of 14 AAAs (53 scans total). Vortices and hemodynamic parameters were estimated using hemodynamic simulations performed to each scan of each patient and compared to local 3D changes of ILT thickness between two consecutive scans (ΔILT). Results showed that vortices formed and remained strong and close to the lumen surface in AAAs without an ILT, while in AAAs with ILTs these detached from the lumen surface and dissipated nearby wall region where an increase in ILT thickness was observed. Although low TAWSS was observed in regions with and without ILT accumulation, an inverse correlation between ∆ILT and TAWSS was observed within the regions that experienced a thrombus growth. Our results support the idea that vortical structures might be playing a role modulating ILT accumulation into specific wall regions. Also, it submits the idea that the low TAWSS will be modulating the growth of thrombus within these preferred ILT accumulated regions.

published proceedings

  • International Journal for Numerical Methods in Biomedical Engineering

author list (cited authors)

  • Zambrano, B. A., Gharahi, H., Lim, C. Y., Lee, W., & Baek, S

citation count

  • 0

complete list of authors

  • Zambrano, Byron A||Gharahi, Hamidreza||Lim, Chae Young||Lee, Whal||Baek, Seungik

publication date

  • February 2022