Gravitational effects on intraocular pressure and ocular perfusion pressure Academic Article uri icon


  • Maintaining appropriate ocular perfusion pressure (OPP) is critical for ocular health. We measured the relative changes in intraocular and mean arterial pressures during 360° tilt and calculated OPP, which was elevated during head-down tilt and decreased during head-up tilt. Experimental data are also explained by our computational model. We demonstrate that OPP is more gravitationally dependent than previously recognized and may be a factor in the overall patho-etiology behind the weightlessness-induced spaceflight-associated neuro-ocular syndrome.

published proceedings

  • Journal of Applied Physiology

altmetric score

  • 16.95

author list (cited authors)

  • Petersen, L. G., Whittle, R. S., Lee, J. H., Sieker, J., Carlson, J., Finke, C., ... Diaz-Artiles, A.

citation count

  • 1

complete list of authors

  • Petersen, Lonnie G||Whittle, Richard S||Lee, Justin H||Sieker, Jeremy||Carlson, Joseph||Finke, Colton||Shelton, Cody M||Petersen, Johan CG||Diaz-Artiles, Ana

publication date

  • January 2022