Therapeutic Neovascularization: Contributions from Bioengineering Academic Article

abstract

• A number of pathological entities and surgical interventions could benefit from therapeutic stimulation of new blood vessel formation. Although strategies designed for promoting neovascularization have shown promise in preclinical models, translation to human application has met with limited success when angiogenesis is used as the single therapeutic mechanism. While clinical protocols continue to be optimized, a number of exciting new approaches are being developed. Bioengineering has played an important role in the progress of many of these innovative new strategies. In this review, we present a general outline of therapeutic neovascularization, with an emphasis on investigations using engineering principles to address this vexing clinical problem. In addition, we identify some limitations and suggest areas for future research.

authors

• Patrick, Charles

published proceedings

• Tissue Engineering

altmetric score

• 3

author list (cited authors)

• Brey, E. M., Uriel, S., Patrick, C., Greisler, H. P., & McIntire, L. V.

citation count

• 74

complete list of authors

• Brey, EM||Uriel, S||Patrick, C||Greisler, HP||McIntire, LV

publication date

• March 2005

publisher

• Mary Ann Liebert, Inc., publishers  Publisher

published in

• Tissue Engineering  Journal

keywords

• Angiogenesis Inducing Agents
• Animals
• Biomedical Engineering
• Bioprosthesis
• Blood Vessel Prosthesis
• Blood Vessels
• Drug Delivery Systems
• Endothelial Cells
• Humans
• Ischemia
• Models, Cardiovascular
• Neovascularization, Physiologic
• Tissue Engineering

PubMed Central ID

• 15869435

Digital Object Identifier (DOI)

• 10.1089/ten.2005.11.567

start page

• 567

end page

• 584

volume

• 11

issue

• 3-4

URL

• http://dx.doi.org/10.1089/ten.2005.11.567