Utility & Vascular Assessment Of A Model Tissue Engineered Construct
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Elucidating the mechanisms of vascular assembly at the capillary level is a limiting factor in translating tissue engineering strategies to the reconstructive surgery clinic. At the 2001 NIH Bioengineering Consortium conference entitled "Reparative Medicine: Growing Tissues and Organs", the need for the development of appropriate and innovative in vivo models for studying and designing vascular networks was highlighted. We present here an initial quantitative model that proves to be sensitive to changes in vascular density, is quantitative, allows spatial and temporal measurements of the vasculature, and can be scaled from a single to a multi-component system.