HR job title
- Professor
- Contact Info
- 1 979 436 0346
de Figueiredo, Paul Associate Professor
Positions
- Associate Professor, Microbial Pathogenesis and Immunology, School of Medicine
I have strong interests in elucidating the molecular mechanisms that mediate interactions between the intracellular bacterial pathogen Brucella spp. and host cells.
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Overview
Publications
selected publications
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academic article
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Huang, C., Guo, F., Wang, H., Olivares, J., Dalton Iii, J., Belyanina, O., ... de Figueiredo, P.
(2022).
An automated system for interrogating the evolution of microbial endosymbiosis. Lab on a Chip: miniaturisation for chemistry, physics, biology, materials science and bioengineering.
-
Yang, J., Qin, Q., Van Schaik, E., Samuel, J. E., & de Figueiredo, P.
(2021).
Automated, High-Throughput Detection of Bacterial Adherence to Host Cells. Journal of Visualized Experiments.
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Cao, S., Yuan, Y. e., Qin, Y. H., Zhang, M., de Figueiredo, P., Li, G., & Qin, Q.
(2018).
The pre-rRNA processing factor Nop53 regulates fungal development and pathogenesis via mediating production of reactive oxygen species. Environmental Microbiology.
20(4), 1531-1549.
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Pandey, A., Lin, F., Cabello, A. L., da Costa, L. F., Feng, X., Feng, H., ... Qin, Q.
(2018).
Activation of Host IRE1-Dependent Signaling Axis Contributes the Intracellular Parasitism of Brucella melitensis. Frontiers in Cellular and Infection Microbiology.
8(APR), 103.
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Patrick, K. L., Wojcechowskyj, J. A., Bell, S. L., Riba, M. N., Jing, T., Talmage, S., ... Watson, R. O.
(2018).
Quantitative Yeast Genetic Interaction Profiling of Bacterial Effector Proteins Uncovers a Role for the Human Retromer in Salmonella Infection. Cell Systems.
7(3), 323-338.e6.
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Pandey, A., Ding, S. L., Qin, Q., Gupta, R., Gomez, G., Lin, F., ... de Figueiredo, P.
(2017).
Global Reprogramming of Host Kinase Signaling in Response to Fungal Infection. Cell Host and Microbe.
21(5), 637-649.e6.
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Feng, H., Li, G., Du, S., Yang, S., Li, X., de Figueiredo, P., & Qin, Q.
(2017).
The septin protein Sep4 facilitates host infection by plant fungal pathogens via mediating initiation of infection structure formation. Environmental Microbiology.
19(5), 1730-1749.
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Dickman, M., Williams, B., Li, Y., de Figueiredo, P., & Wolpert, T.
(2017).
Publisher Correction: Reassessing apoptosis in plants. Nature Plants.
3(11), 906-906.
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Mwangi, W., de Figueiredo, P., & Criscitiello, M. F.
(2016).
One Health: Addressing Global Challenges at the Nexus of Human, Animal, and Environmental Health. PLOS Pathogens.
12(9), e1005731-e1005731.
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Pandey, A., Cabello, A., Akoolo, L., Rice-Ficht, A., Arenas-Gamboa, A., McMurray, D., Ficht, T. A., & de Figueiredo, P.
(2016).
The Case for Live Attenuated Vaccines against the Neglected Zoonotic Diseases Brucellosis and Bovine Tuberculosis. 10(8), e0004572-e0004572.
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Case, E., Smith, J. A., Ficht, T. A., Samuel, J. E., & de Figueiredo, P.
(2016).
Space: A Final Frontier for Vacuolar Pathogens. Traffic.
17(5), 461-474.
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Yang, G., Erbay, C., Yi, S., de Figueiredo, P., Sadr, R., Han, A., & Yu, C.
(2016).
Bifunctional nano-sponges serving as non-precious metal catalysts and self-standing cathodes for high performance fuel cell applications. NANO ENERGY.
22, 607-614.
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de Figueiredo, P., & Dickman, M.
(2016).
Autophagy under attack. eLife.
5(FEBRUARY2016), e14447.
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Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Arozena, A. A., ... Bagniewska-Zadworna, A.
(2016).
Erratum. Autophagy.
12(2), 443-443.
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Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., ... Zughaier, S. M.
(2016).
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy.
12(1), 1-222.
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de Figueiredo, P., Ficht, T. A., Rice-Ficht, A., Rossetti, C. A., & Adams, L. G.
(2015).
Pathogenesis and immunobiology of brucellosis: review of Brucella-host interactions. American Journal of Pathology.
185(6), 1505-1517.
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Guzman, A. R., Kim, H. S., de Figueiredo, P., & Han, A.
(2015).
A three-dimensional electrode for highly efficient electrocoalescence-based droplet merging. Biomedical Microdevices.
17(2), 35.
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Erbay, C., Pu, X., Choi, W., Choi, M., Ryu, Y., Hou, H., ... Han, A.
(2015).
Control of geometrical properties of carbon nanotube electrodes towards high-performance microbial fuel cells. Journal of Power Sources.
280, 347-354.
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Erbay, C., Yang, G., de Figueiredo, P., Sadr, R., Yu, C., & Han, A.
(2015).
Three-dimensional porous carbon nanotube sponges for high-performance anodes of microbial fuel cells. Journal of Power Sources.
298, 177-183.
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de Figueiredo, P., Terra, B., Anand, J. K., Hikita, T., Sadilek, M., Monks, D. E., ... Nester, E. W.
(2014).
A catalytic carbohydrate contributes to bacterial antibiotic resistance. Extremophiles.
11(1), 133-143.
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Pandey, A., Ding, S. L., Ficht, T. A., & de Figueiredo, P.
(2014).
SiRNA screens using Drosophila cells to identify host factors required for infection. Methods in Molecular Biology.
1197, 229-244.
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Dickman, M. B., & de Figueiredo, P.
(2013).
Death be not proud--cell death control in plant fungal interactions. PLOS Pathogens.
9(9), e1003542-e1003542.
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Criscitiello, M. F., Dickman, M. B., Samuel, J. E., & de Figueiredo, P.
(2013).
Tripping on acid: trans-kingdom perspectives on biological acids in immunity and pathogenesis. PLOS Pathogens.
9(7), e1003402-e1003402.
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Han, A., Hou, H., Li, L., Kim, H. S., & de Figueiredo, P.
(2013).
Microfabricated devices in microbial bioenergy sciences. Trends in Biotechnology.
31(4), 225-232.
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Criscitiello, M. F., & de Figueiredo, P.
(2013).
Fifty shades of immune defense. PLOS Pathogens.
9(2), e1003110-e1003110.
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Ancona, V., Appel, D. N., & de Figueiredo, P.
(2013).
Xylella fastidiosa: a model for analyzing agricultural biosecurity. Biosecurity and Bioterrorism: biodefense strategy, practice and science.
8(2), 171-182.
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Hou, H., Li, L., Ceylan, C., Haynes, A., Cope, J., Wilkinson, H. H., ... Han, A.
(2012).
A microfluidic microbial fuel cell array that supports long-term multiplexed analyses of electricigens. Lab on a Chip: miniaturisation for chemistry, physics, biology, materials science and bioengineering.
12(20), 4151-4159.
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de Figueiredo, P., Doody, A., Polizotto, R. S., Drecktrah, D., Wood, S., Banta, M., Strang, M. S., & Brown, W. J.
(2012).
Inhibition of transferrin recycling and endosome tubulation by phospholipase A2 antagonists. Journal of Biological Chemistry.
276(50), 47361-47370.
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Dickman, M. B., & Figueiredo, P. D.
(2011).
Comparative pathobiology of fungal pathogens of plants and animals. PLOS Pathogens.
7(12), e1002324-e1002324.
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Qin, Q., Luo, J., Lin, X., Pei, J., Li, L., Ficht, T. A., & de Figueiredo, P.
(2011).
Functional analysis of host factors that mediate the intracellular lifestyle of Cryptococcus neoformans. PLOS Pathogens.
7(6), e1002078-e1002078.
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Hou, H., Li, L., de Figueiredo, P., & Han, A.
(2011).
Air-cathode microbial fuel cell array: a device for identifying and characterizing electrochemically active microbes. Biosensors and Bioelectronics.
26(5), 2680-2684.
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Dodsworth, J. A., Li, L., Wei, S., Hedlund, B. P., Leigh, J. A., & de Figueiredo, P.
(2010).
Interdomain conjugal transfer of DNA from bacteria to archaea. Applied and Environmental Microbiology.
76(16), 5644-5647.
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Jupiter, D. C., Ficht, T. A., Samuel, J., Qin, Q., & de Figueiredo, P.
(2010).
DNA watermarking of infectious agents: progress and prospects. PLOS Pathogens.
6(6), e1000950-e1000950.
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Jupiter, D., Ficht, T., Qin, Q., Rice-Ficht, A., Samuel, J., & de Figueiredo, P.
(2010).
Genomic polymorphisms as inherent watermarks for tracking infectious agents. Frontiers in Microbiology.
1(SEP), 109.
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Hou, H., Li, L., Cho, Y., de Figueiredo, P., & Han, A.
(2009).
Microfabricated Microbial Fuel Cell Arrays Reveal Electrochemically Active Microbes. PLoS One.
4(8),
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Hou, H., Li, L., Cho, Y., de Figueiredo, P., & Han, A.
(2009).
Microfabricated microbial fuel cell arrays reveal electrochemically active microbes. ACS National Meeting Book of Abstracts.
4(8), e6570-e6570.
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Qin, Q., Pei, J., Ancona, V., Shaw, B. D., Ficht, T. A., & de Figueiredo, P.
(2008).
RNAi screen of endoplasmic reticulum-associated host factors reveals a role for IRE1alpha in supporting Brucella replication. PLOS Pathogens.
4(7), e1000110-e1000110.
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Ditt, R. F., Kerr, K. F., de Figueiredo, P., Delrow, J., Comai, L., & Nester, E. W.
(2006).
The Arabidopsis thaliana transcriptome in response to Agrobacterium tumefaciens. Molecular Plant-Microbe Interactions.
19(6), 665-681.
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de Figueiredo, P., Roberts, R. L., & Nester, E. W.
(2004).
DARTs: A DNA-based in vitro polypeptide display technology. Proteomics.
4(10), 3128-3140.
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de Figueiredo, P., Drecktrah, D., Polizotto, R. S., Cole, N. B., Lippincott-Schwartz, J., & Brown, W. J.
(2000).
Phospholipase A2 antagonists inhibit constitutive retrograde membrane traffic to the endoplasmic reticulum. Traffic.
1(6), 504-511.
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Polizotto, R. S., de Figueiredo, P., & Brown, W. J.
(1999).
Stimulation of Golgi membrane tubulation and retrograde trafficking to the ER by phospholipase A(2) activating protein (PLAP) peptide. Journal of Cellular Biochemistry.
74(4), 670-683.
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de Figueiredo, P., Polizotto, R. S., Drecktrah, D., & Brown, W. J.
(1999).
Membrane tubule-mediated reassembly and maintenance of the Golgi complex is disrupted by phospholipase A2 antagonists. Molecular Biology of the Cell.
10(6), 1763-1782.
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de Figueiredo, P., Drecktrah, D., Katzenellenbogen, J. A., Strang, M., & Brown, W. J.
(1998).
Evidence that phospholipase A2 activity is required for Golgi complex and trans Golgi network membrane tubulation. Proceedings of the National Academy of Sciences of USA.
95(15), 8642-8647.
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Drecktrah, D., de Figueiredo, P., Mason, R. M., & Brown, W. J.
(1998).
Retrograde trafficking of both Golgi complex and TGN markers to the ER induced by nordihydroguaiaretic acid and cyclofenil diphenol. Journal of Cell Science.
111 ( Pt 7)(7), 951-965.
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Banta, M., Polizotto, R. S., Wood, S. A., de Figueiredo, P., & Brown, W. J.
(1995).
Characterization of a cytosolic activity that induces the formation of Golgi membrane tubules in a cell-free reconstitution system. Biochemistry.
34(41), 13359-13366.
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de Figueiredo, P., & Brown, W. J.
(1995).
A role for calmodulin in organelle membrane tubulation. Molecular Biology of the Cell.
6(7), 871-887.
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Bechler, M. E., de Figueiredo, P., & Brown, W. J.
A PLA1-2 punch regulates the Golgi complex. Trends in Cell Biology.
22(2), 116-124.
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de Figueiredo, P., & Brown, W. J.
Clofibrate inhibits membrane trafficking to the Golgi complex and induces its retrograde movement to the endoplasmic reticulum. Cell Biology and Toxicology: an international journal devoted to research at the cellular level.
15(5), 311-323.
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Huang, C., Guo, F., Wang, H., Olivares, J., Dalton Iii, J., Belyanina, O., ... de Figueiredo, P.
(2022).
An automated system for interrogating the evolution of microbial endosymbiosis. Lab on a Chip: miniaturisation for chemistry, physics, biology, materials science and bioengineering.
-
chapter
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Cluett, E. B., de Figueiredo, P., Bechler, M. E., Thorsen, K. D., & Brown, W. J.
(2016).
Reconstitution of Phospholipase A2-Dependent Golgi Membrane Tubules. Methods in Molecular Biology.
GOLGI COMPLEX: METHODS AND PROTOCOLS.
(pp. 75-90).
Springer Nature.
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Kalkofen, D. N., de Figueiredo, P., & Brown, W. J.
(2015).
Methods for analyzing the role of phospholipase A enzymes in endosome membrane tubule formation. SORTING AND RECYCLING ENDOSOMES.
(pp. 157-180).
Elsevier.
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Hou, H., Li, L., Cho, Y., de Figueiredo, P., & Han, A.
(2011).
Microfabricated Microbial Fuel Cell Arrays. Recent Advances in Microbiology.
(pp. 1-12).
Taylor & Francis.
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Cluett, E. B., de Figueiredo, P., Bechler, M. E., Thorsen, K. D., & Brown, W. J.
(2016).
Reconstitution of Phospholipase A2-Dependent Golgi Membrane Tubules. Methods in Molecular Biology.
GOLGI COMPLEX: METHODS AND PROTOCOLS.
(pp. 75-90).
Springer Nature.
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conference paper
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Huang, C., Wang, H., De Figueiredo, P., & Han, A.
(2019).
AUTOMATIC MEMBRANE-BASED MICROFLUIDIC PLATFORM FOR INVESTIGATING THE EMERGENCE OF PATHOGENICITY. 2239-2242.
-
Erbay, C., Pu, X., Choi, W., Choi, M., Hou, H., Figueiredo, P., Yu, C., & Han, A.
(2014).
Effect of physical properties of carbon nanotube anodes on microfluidic microbial fuel cell array. 1933-1935.
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Mijalis, A. J., Mallepally, R., de Figueiredo, P., & Kenerley, C.
(2012).
Invisible jungle. ACS National Meeting Book of Abstracts.
-
Hou, H., Li, L., De Figueiredo, P., & Han, A.
(2011).
Microfluidic microbial fuel cell array for multiplexed long-term parallel analysis of microbial activities. 1424-1426.
-
Hou, H., Ceylan, C. U., Li, L., De Figueiredo, P., & Han, A.
(2010).
A microfluidic microbial fuel cell array for electrochemically-active microbe screening and analysis. 677-679.
-
Ancona, V., Appel, D. N., & de Figueiredo, P.
(2010).
Regulatory role of c-di-GMP biosynthesis genes of Xylella fastidiosa's virulence factors. Phytopathology: International Journal of the American Phytopathological Society.
S7-S7.
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Hou, H., Li, L., Cho, Y., de Figueiredo, P., & Han, A.
(2010).
A MICROFABRICATED MICROBIAL FUEL CELL ARRAY FOR HIGH THROUGHPUT SCREENING (HTS) OF ELECTRICITY GENERATING MICROBES FROM ENVIRONMENT. Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS).
1191-1194.
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Ancona, V., & de Figueiredo, P.
(2009).
Regulation of c-di-GMP intracellular levels in X. fastidiosa. Phytopathology: International Journal of the American Phytopathological Society.
S4-S4.
-
Guo, J., Knight, C., Gruber, C., Blackwell, J., Garrido-Lecca, A., Russell, W. K., ... Huang, J.
(2009).
SDO1P REGULATION OF HISTONE DEACETYLASE ACTIVITY IN YEAST. PEDIATRIC BLOOD & CANCER.
698-698.
-
Ancona, V., Wei, S., Appel, D., Hayakawa, Y., & DeFigueiredo, P. J.
(2008).
C-diGMP regulation of Xylella fastidiosa Temecula gene expression and biofilm formation. Phytopathology: International Journal of the American Phytopathological Society.
S13-S13.
-
Huang, C., Wang, H., De Figueiredo, P., & Han, A.
(2019).
AUTOMATIC MEMBRANE-BASED MICROFLUIDIC PLATFORM FOR INVESTIGATING THE EMERGENCE OF PATHOGENICITY. 2239-2242.
Research
principal investigator on
- Development of a High-Throughput Microfludics-Enabled Functional Assay for Rapidly Identifying Neutralizing Antibodies awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2019 - 2024
- Accelerating Discovery of Neutralizing Paratopes with Functional Antibody Screening Technology awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2020 - 2021
- RAPID: Large-scale functional analysis of antibody repertoires elicited by SARS-CoV-2 awarded by Directorate for Biological Sciences - (Arlington, Virginia, United States) 2020 - 2021
- PolyChip รข An Ultra High Throughput Microfluidic Functional Assay Strategy for Antimicrobial Drug Discovery. awarded by Qatar National Research Fund - (Doha, Qatar) 2016 - 2019
- Self-sustainable and Highly Efficient Desalination System based on Microbe-Nanostructure Hybrids awarded by Qatar National Research Fund - (Doha, Qatar) 2015 - 2018
co-principal investigator on
- An Ultra-high Throughput Microfluidic System for 3-D Assembly of Microbial Communities awarded by United States Army - (Washington D.C., District of Columbia, United States) 2019 - 2021
- MIRROR: A Chip-Scale Mid-IR Ring Resonance System for On-the-fly Reporting of Analytes awarded by National Institutes of Health - (Bethesda, Maryland, United States) 2019 - 2021
- iSENTRY: An Integrated Microfluidics-Enabled System for Phenotypic Detection of Biothreat Agents awarded by United States Department of Defense - (Washington D.C., District of Columbia, United States) 2018 - 2020
- MRI: Development of a microfluidic flow cytometer for high-throughput non-invasive single-cell physio-chemical analysis awarded by National Science Foundation - (Arlington, Virginia, United States) 2015 - 2019
investigator on
Teaching
teaching activities
- BESC485 Hnr-directed Studies Instructor
- BIOT685 Directed Studies Instructor
- GENE491 Hnr-research Instructor
- MSCI681 Seminar Instructor
- MSCI691 Research Credit: Medical Sci Instructor
- NUTR491 Research Instructor
- UGST285 Directed Studies Instructor
Background
education and training
- Ph.D. in Biochemistry, Molecular, and Cell Biology, Vertebrate Genetics, Cornell University - (Ithaca, New York, United States) 1997
- M.A. in Religious Studies, Stanford University - (Stanford, California, United States) 1989
- B.A. in Mathematics and Political Science, Rice University - (Houston, Texas, United States) 1986
- University of Washington - (Seattle, Washington, United States) , Postdoctoral Training 2005
- Massachusetts Institute of Technology - (Cambridge, Massachusetts, United States) , Postdoctoral Training 1999
Contact
first name
- Paul
has last name
- de Figueiredo
mailing address
-
Texas A&M Health Science Center
Microbial Pathogenesis And Immunology
1114 TAMUS
Bryan, TX 77807
USA
Other
In the News
- pjdefigueiredo@tamu.edu