A phenomenological model of the synapse between the inner hair cell and auditory nerve: Implications of limited neurotransmitter release sites. Academic Article

abstract

• Peterson and Heil [Hear. Res., In Press] have argued that the statistics of spontaneous spiking in auditory nerve fibers (ANFs) can be best explained by a model with a limited number of synaptic vesicle docking (release) sites (4) and a relatively-long average redocking time (16-17 ms) for each of the sites. In this paper we demonstrate how their model can be: i) generalized to also describe sound-driven ANF responses and ii) incorporated into a well-established and widely-used model of the entire auditory periphery [Zilany etal., J. Acoust. Soc. Am. 135, 283-286, 2014]. The responses of the new model exhibit substantial improvement in several measures of ANF spiking statistics, and predicted physiological forward-masking and rate-level functions from the new model structure are shown to also better match published physiological data.

authors

• Zilany, Muhammad Shamsul Arefeen

published proceedings

• Hear Res

author list (cited authors)

• Bruce, I. C., Erfani, Y., & Zilany, M.

citation count

• 66

complete list of authors

• Bruce, Ian C||Erfani, Yousof||Zilany, Muhammad SA

publication date

• January 2018

publisher

• Elsevier  Publisher

published in

• Hearing Research  Journal

keywords

• Acoustic Stimulation
• Animals
• Auditory Model
• Auditory Pathways
• Auditory Perception
• Cochlear Nerve
• Computer Simulation
• Exocytosis
• Hair Cells, Auditory, Inner
• Hearing
• Humans
• Kinetics
• Models, Neurological
• Neurotransmitter Vesicle Release
• Refractoriness
• Renewal Process
• Spike Timing Statistics
• Synapse
• Synaptic Potentials
• Synaptic Transmission
• Synaptic Vesicles

PubMed Central ID

• 29395616

Digital Object Identifier (DOI)

• 10.1016/j.heares.2017.12.016

start page

• 40

end page

• 54

volume

• 360

URL

• http://dx.doi.org/10.1016/j.heares.2017.12.016