Degradable polyphosphoester-based silver-loaded nanoparticles as therapeutics for bacterial lung infections. Academic Article uri icon

abstract

  • In this study, a new type of degradable polyphosphoester-based polymeric nanoparticle, capable of carrying silver cations via interactions with alkyne groups, has been developed as a potentially effective and safe treatment for lung infections. It was found that up to 15% (w/w) silver loading into the nanoparticles could be achieved, consuming most of the pendant alkyne groups along the backbone, as revealed by Raman spectroscopy. The well-defined Ag-loaded nanoparticles released silver in a controlled and sustained manner over 5 days, and displayed enhanced in vitro antibacterial activities against cystic fibrosis-associated pathogens and decreased cytotoxicity to human bronchial epithelial cells, in comparison to silver acetate.

published proceedings

  • Nanoscale

author list (cited authors)

  • Zhang, F., Smolen, J. A., Zhang, S., Li, R., Shah, P. N., Cho, S., ... Wooley, K. L.

citation count

  • 56

complete list of authors

  • Zhang, Fuwu||Smolen, Justin A||Zhang, Shiyi||Li, Richen||Shah, Parth N||Cho, Sangho||Wang, Hai||Raymond, Jeffery E||Cannon, Carolyn L||Wooley, Karen L

publication date

  • February 2015