Degradable polyphosphoester-based silver-loaded nanoparticles as therapeutics for bacterial lung infections Academic Article uri icon

abstract

  • In this study, a new type of degradable polyphosphoester-based polymeric nanoparticle, capable of carrying silver cations via interactions with alkyne groups, has been developed as a potentially effective and safe treatment for lung infections. It was found that up to 15% (w/w) silver loading into the nanoparticles could be achieved, consuming most of the pendant alkyne groups along the backbone, as revealed by Raman spectroscopy. The well-defined Ag-loaded nanoparticles released silver in a controlled and sustained manner over 5 days, and displayed enhanced in vitro antibacterial activities against cystic fibrosis-associated pathogens and decreased cytotoxicity to human bronchial epithelial cells, in comparison to silver acetate.

author list (cited authors)

  • Zhang, F., Smolen, J. A., Zhang, S., Li, R., Shah, P. N., Cho, S., ... Wooley, K. L.

citation count

  • 45

publication date

  • February 2015