Enhancing the protein resistance of silicone via surface-restructuring PEO-silane amphiphiles with variable PEO length. Academic Article uri icon


  • Silicones with superior protein resistance were produced by bulk-modification with poly(ethylene oxide) (PEO)-silane amphiphiles that demonstrated a higher capacity to restructure to the surface-water interface versus conventional non-amphiphilic PEO-silanes. The PEO-silane amphiphiles were prepared with a single siloxane tether length but variable PEO segment lengths: -(EtO)3Si(CH2)2-oligodimethylsiloxane13-block-poly(ethylene oxide) n -OCH3 (n = 3, 8, and 16). Conventional PEO-silane analogues (n = 3, 8 and 16) as well as a siloxane tether-silane (i.e. no PEO segment) were prepared as controls. When surface-grafted onto silicon wafer, PEO-silane amphiphiles produced surfaces that were more hydrophobic and thus more adherent towards fibrinogen versus the corresponding PEO-silane. However, when blended into a silicone, PEO-silane amphiphiles exhibited rapid restructuring to the surface-water interface and excellent protein resistance whereas the PEO-silanes did not. Silicones modified with PEO-silane amphiphiles of PEO segment lengths n = 8 and 16 achieved the highest protein resistance.

published proceedings

  • J Mater Chem B

altmetric score

  • 3

author list (cited authors)

  • Rufin, M. A., Gruetzner, J. A., Hurley, M. J., Hawkins, M. L., Raymond, E. S., Raymond, J. E., & Grunlan, M. A.

citation count

  • 33

complete list of authors

  • Rufin, MA||Gruetzner, JA||Hurley, MJ||Hawkins, ML||Raymond, ES||Raymond, JE||Grunlan, MA

publication date

  • April 2015