Frequency of signs of chronic gastrointestinal disease in dogs after an episode of acute hemorrhagic diarrhea.
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BACKGROUND: Acute enteropathy is a trigger of chronic gastrointestinal (GI) disease in humans. OBJECTIVE: To report the prevalence of and explore possible risk factors for signs of chronic GI disease in dogs after an episode of acute hemorrhagic diarrhea (AHD). ANIMALS: One hundred and fifty-one dogs, 80 dogs with a historical diagnosis of AHD, 71 control dogs with no history of AHD. METHODS: In this retrospective longitudinal study, data were collected from dogs with a historical diagnosis of AHD and healthy controls matched by breed, age and sex, aged between 1year and 15years of age, for which a follow-up of at least 12months after enrolment was available. Dog owners responded to a questionnaire to determine the history of signs of chronic GI disease. RESULTS: There was a higher prevalence of signs of chronic GI disease in the dogs with a previous episode of AHD compared to control dogs (AHD 28%; controls 13%; P=.03; odds ratio=2.57; confidence interval [CI] 95% 1.12-6.31) over a similar observation time (median 4years; range, 1-12years). CONCLUSIONS AND CLINICAL IMPORTANCE: Severe intestinal mucosal damage and associated barrier dysfunction might trigger chronic GI disease later in life.
author list (cited authors)
Skotnitzki, E., Suchodolski, J. S., Busch, K., Werner, M., Zablotski, Y., Ballhausen, B. D., Neuerer, F., & Unterer, S.
complete list of authors
Skotnitzki, Elisabeth||Suchodolski, Jan S||Busch, Kathrin||Werner, Melanie||Zablotski, Yury||Ballhausen, Bianca D||Neuerer, Felix||Unterer, Stefan