Assessing the Feasibility of Dynamic 31P Spectroscopy for Metabolic Studies With a 1.0T Extremity Scanner. Academic Article uri icon


  • OBJECTIVE: The feasibility of conducting in vivo non-localized 31P Magnetic Resonance Spectroscopy (MRS) with a 1.0T extremity scanner and the potential to increase accessibility of this important diagnostic tool for low cost applications is revisited. METHODS: This work presents a custom transmit-only quadrature birdcage, four-element receive coil array, and spectrometer interfaced to a commercial ONI 1.0T magnet for enabling multi-channel, non-1H frequency capabilities. A custom, magnetic resonance compatible plantar flexion-extension exercise device was also developed to enable exercise protocols. The coils were assessed with bench measurements and 31P phantom studies before an in vivo demonstration. RESULTS: In pulse and acquire spectroscopy of a phantom, the array was found to improve the signal-to-noise ratio (SNR) by a factor of 1.31 and reduce the linewidth by 13.9% when compared to a large loop coil of the same overall size. In vivo testing results show that two averages and a four second repetition time for a temporal resolution of eight seconds was sufficient to obtain phosphocreatine recovery values and baseline pH levels aligned with expected literature values. CONCLUSION: Initial in vivo human skeletal muscle 31P MRS allowed successful monitoring of metabolic changes during an 18-minute exercise protocol. SIGNIFICANCE: Adding an array coil and multinuclear capability to a commercial low-cost 1.0T extremity scanner enabled the observation of characteristic 31P metabolic information, such as the phosphocreatinerecovery rate and underlying baseline pH.

published proceedings

  • IEEE Trans Biomed Eng

author list (cited authors)

  • Carrell, T., Gu, M., Bosshard, J. C., Sun, C., McDougall, M. P., & Wright, S. M.

citation count

  • 0

complete list of authors

  • Carrell, Travis||Gu, Minyu||Bosshard, John C||Sun, Chenhao||McDougall, Mary P||Wright, Steven M

publication date

  • June 2022