Direct Interstitial Decongestion in an Animal Model of Acute-on-Chronic Ischemic HeartFailure. Academic Article

abstract

• Removal of excess fluid in acute decompensated heart failure (ADHF) targets the intravascular space, whereas most fluid resides in the interstitial space. The authors evaluated an approach to interstitial decongestion using a device to enhance lymph flow. The device was deployed in sheep with induced heart failure (HF) and acute volume overload to create a low-pressure zone at the thoracic duct outlet. Treatment decreased extravascular lung water (EVLW) volume (mL/kg) (-32% 9%, P=0.029) compared to controls (+46% 9%, P=0.003). Device-mediated thoracic duct decompression effectively reduced EVLW. Human studies may establish device-based interstitial decongestion as a new ADHF treatment.

authors

• Dongaonkar, Ranjeet

published proceedings

• JACC Basic Transl Sci

altmetric score

• 16.65

author list (cited authors)

• Abraham, W. T., Jonas, M., Dongaonkar, R. M., Geist, B., Ueyama, Y., Render, K., ... Del Rio, C. L.

citation count

• 13

complete list of authors

• Abraham, William T||Jonas, Michael||Dongaonkar, Ranjeet M||Geist, Beth||Ueyama, Yukie||Render, Kevin||Youngblood, Brad||Muir, William||Hamlin, Robert||Del Rio, Carlos L

publication date

• January 2021

publisher

• Elsevier  Publisher

published in

• JACC: Basic to Translational Science  Journal

keywords

• Acute Decompensated Heart Failure
• Adhf, Acute Decompensated Heart Failure
• Cvp, Central Venous Pressure
• Decongestion
• Evlw, Extravascular Lung Water
• Interstitial
• Lymphatic
• Pulmonary Edema
• Thoracic Duct
• Volume Overload

PubMed Central ID

• 34869951

Digital Object Identifier (DOI)

• 10.1016/j.jacbts.2021.09.008

start page

• 872

end page

• 881

volume

• 6

issue

• 11

URL

• http://dx.doi.org/10.1016/j.jacbts.2021.09.008