Fe-Catalyzed dicarbofunctionalization of electron-rich alkenes with Grignard reagents and (fluoro)alkyl halides. Academic Article uri icon


  • An iron-catalyzed regioselective dicarbofunctionalization of electron-rich alkenes is described. In particular, aryl- and alkyl vinyl ethers are used as effective linchpins to couple alkyl or (fluoro)alkyl halides and sp2-hybridized Grignard nucleophiles. Preliminary results demonstrate the ability to engage thioethers as linchpins and control enantioselectivity in these transformations, an area which is largely unexplored in iron-catalyzed three-component cross-coupling reactions.

published proceedings

  • Chem Commun (Camb)

author list (cited authors)

  • Rotella, M. E., Sar, D., Liu, L., & Gutierrez, O.

complete list of authors

  • Rotella, Madeline E||Sar, Dinabandhu||Liu, Lei||Gutierrez, Osvaldo

publication date

  • November 2021