Expression of chimeric antigen receptor therapy targets detected by single-cell sequencing of normal cells may contribute to off-tumor toxicity.
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Jing, Y., Liu, Y., Li, Q., Ye, Y., Diao, L., Huang, Y., ... Han, L.
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Jing, Ying||Liu, Yuan||Li, Qiang||Ye, Youqiong||Diao, Lixia||Huang, Yun||Zhou, Yubin||Green, Michael R||Mills, Gordon B||Han, Leng
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Humans
Immunotherapy, Adoptive
Neoplasms
Receptors, Chimeric Antigen
Single-Cell Analysis
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http://dx.doi.org/10.1016/j.ccell.2021.09.016