Correlation of cytology to histology in a case of canine granulomatous colitis in a Boxer dog. Academic Article uri icon


  • A 2-year-old castrated male mixed breed dog presented to the North Carolina State Veterinary Teaching Hospital for chronic diarrhea with hematochezia and weight loss. Cytology performed on a rectal scraping revealed macrophages containing magenta, light pink, and variably blue granular inclusions, and phagocytosed material concerning for infectious organisms. Histopathology was consistent with granulomatous colitis and identified intra-histiocytic bacterial organisms, confirmed by fluorescent in situ hybridization (FISH)-tissue culture-confirmed Escherichia coli. Based on these findings, a diagnosis of granulomatous colitis was made. The patient was successfully treated with oral enrofloxacin, and near-complete remission of signs was achieved within 6weeks. This report describes a case of granulomatous colitis in a mixed breed dog, and is the first published description of the cytologic features of this uncommon disease, offering a valuable cytologic-histologic correlation. In this case, the cytology was helpful in identifying features consistent with granulomatous colitis and prioritizing the differential diagnoses and diagnostic plan.

published proceedings

  • Vet Clin Pathol

altmetric score

  • 0.5

author list (cited authors)

  • Sims, C. S., Nagle, J., Tolbert, M. K., Anderson, K., Linder, K., & Neel, J.

citation count

  • 1

complete list of authors

  • Sims, Cory S||Nagle, Jonathan||Tolbert, M Katherine||Anderson, Katie||Linder, Keith||Neel, Jennifer

publication date

  • January 2022