A micro electrochemical sensor for detecting the presence or measuring the quantity of a target analyte in a sample includes a substrate, a detection chamber, micro reservoirs, and micro channels. The detection chamber includes a miniaturized electrochemical sensor comprising electrodes including a working electrode, a reference electrode, and an auxiliary (counter) electrode, on a substrate by combining micro-fluidics. The present invention is compatible with micro-electro-mechanical systems (MEMS) and integrated circuit (IC) technology. The sensor utilizes a method to enhance adsorption with the use of micro pillars and the use of diffusion alone by directing the reagent and/or solution containing biological analyte or material with the help of micro-channels.
