Assembly and Transport Properties of Nanoscale Biopolyelectrolyte Multilayers Academic Article

abstract

• Nanoscale coatings are attractive for managing the biological/material interface as well as for transport control in medical device applications. Construction of biologically derived and mimicking polyelectrolyte multilayers (BioPEMs) and their chemically crosslinked derivatives was evaluated at the nanometer scale and the glucose mass transfer properties were characterized in a physiological environment. Glucose diffusivity through all the BioPEMs was found to be three to four orders of magnitude lower than that of bare substrate. In contrast, permeation rates (dC/dt) were significantly higher than when compared to films comprising the same number of bilayers of synthetic materialspoly(acrylic acid)/poly(allylamine hydrochloride). Crosslinked BioPEMs exhibited decreased diffusivity of glucose up to 51% compared to native BioPEMs. These findings provide fundamental insight into the transport properties of BioPEM coatings that may be useful in maximizing biomimetic properties while also controlling permeation of small molecules in applications such as sensors, filtration, and drug delivery systems.

authors

• McShane, Michael

published proceedings

• COATINGS

altmetric score

• 0.5

author list (cited authors)

• Park, J., & McShane, M. J.

citation count

• 0

complete list of authors

• Park, Jaebum||McShane, Michael J

publication date

• January 2021

publisher

• MDPI  Publisher

published in

• Coatings  Journal

keywords

• Biocompatibility
• Biopolymers
• Biosensors
• Diffusion Limiting
• Drug Delivery
• Polyelectrolyte Multilayer
• Polysaccharides
• Transport Control

Digital Object Identifier (DOI)

• 10.3390/coatings11091024

start page

• 1024

end page

• 1024

volume

• 11

issue

• 9

URL

• http://dx.doi.org/10.3390/coatings11091024