Mosaic chimeric viral vaccine particle Patent uri icon


  • The present invention describes compositions and methods for priming protective immunity in the presence of pre-existing maternal antibody. In some embodiments, the invention contemplates simultaneously masking vaccines to avoid antibody neutralization while targeting those vaccines to specific cell types in order to elicit an enhanced immune response. In other embodiments, vectors that recruit and activate specific antigen-presenting cells may further enhance the efficacy of those immune responses.

author list (cited authors)

  • Mwangi, W., Waghela, S., & Berghman, L.

complete list of authors

  • Mwangi, Waithaka||Waghela, Surya||Berghman, Luc

publication date

  • November 2020