Compositions and methods of enhancing immune responses to enteric pathogens Patent uri icon


  • Vaccine vectors capable of eliciting an immune response to enteric bacteria and methods of using the same are provided. The vaccine vectors include a polynucleotide encoding a PAL polypeptide. The PAL polypeptide may be expressed on the surface of the vaccine vector. The vaccine vector may also include a second polypeptide encoding an immunostimulatory polypeptide such as a CD154 polypeptide or an HMGB1 polypeptide.

author list (cited authors)

  • Bielke, L., Layton, S., Pumford, N. R., Faulkner, O. B., Berghman, L., & Aby-Ghanem, D.

complete list of authors

  • Bielke, Lisa||Layton, Sherryll||Pumford, Neil R||Faulkner, Olivia B||Berghman, Luc||Aby-Ghanem, Daad

publication date

  • July 2020