New insights on liver abscess syndrome in cattle using metagenomic investigations Conference Paper uri icon


  • Abstract Liver abscess syndrome (LAS) is a well-recognized and important problem for beef production in all types of cattle. LAS has been shown to be associated with decreased growth efficiency and lower carcass quality, in addition to losses associated with carcass trimming and condemnation of materials at slaughter. The etiopathogenesis of LAS has traditionally attributed a few bacterial species as being the principal causes (Fusobacterium necrophorum, and Trueperella pyogenes), based on the theory that these bacteria are translocated from the rumen into portal circulation, allowing them to seed the liver. Research regarding the pathogenesis and prevention of LAS has long been limited to data derived from culture-based investigations. Advances in genomic sequencing provide tremendous opportunities for re-evaluation of traditional perspectives on LAS. Recent metagenomic investigations of liver abscesses conducted by our research team have found that liver abscesses are far more polymicrobial than previously believed, suggesting that the etiology is more complex than previously believed. This presentation will present data from culture-based investigations and those using metagenomic sequencing as we re-evaluate traditional dogma regarding LAS.

published proceedings


author list (cited authors)

  • Morley, P. S.

citation count

  • 0

complete list of authors

  • Morley, Paul S

publication date

  • November 2020