Performance, health, and physiological responses of newly received feedlot cattle supplemented with pre- and probiotic ingredients. Academic Article uri icon


  • Nutritional strategies that optimize immunity of feedlot cattle are warranted due to increasing regulations with the use of feed-grade antimicrobials. This study evaluated physiological, health, and performance responses of cattle receiving a synbiotic supplement (yeast-derived prebiotic+Bacillus subtilis probiotic), which replaced feed-grade antimicrobials or were fed in conjunction with monensin during the initial 45days in the feedlot. Angus-influenced steers (n=256) were acquired from an auction facility on day -2, and transported (800km) to the feedlot. Shrunk BW was recorded upon arrival (day -1). Steers were allocated to 1 of 18 pens (day 0), and pens were assigned to receive (n=6/treatment) a free-choice diet containing: (1) monensin and tylosin (RT; 360mg/steer daily from Rumensin and 90mg/steer daily from Tylan; Elanco Animal Health, Greenfield, IN, USA), (2) yeast-derived ingredient and B. subtilis probiotic (CC; 18g/steer daily of Celmanax and 28g/steer daily of Certillus; Church and Dwight Co., Inc., Princeton, NJ, USA), or (3) monensin in addition to yeast-derived and B. subtilis ingredients (RCC) as in RT and CC. Steers were assessed for bovine respiratory disease (BRD) and DMI daily. Steer BW was recorded on days 45 and 46, and averaged for final BW. Blood samples were collected on days 0, 7, 17, 31, and 45. Feed intake was greater (P0.05) in CC vs. RCC and RT during the initial 3weeks upon feedlot arrival. No treatment differences were noted (P0.41) for average daily gain, BW, and feed efficiency. Incidence of BRD did not differ (P=0.77) between treatments (average 80.1%). A greater proportion (P0.03) of RT steers diagnosed with BRD required a second antimicrobial treatment compared with CC and RCC (57.3, 37.3, and 38.6%, respectively). Removal of steers from the trial due to severe morbidity+mortality was greater (P=0.02) in RT vs. CC (22.4 and 7.0%), and did not differ (P0.16) among RCC (12.9%) vs. RT and CC. Plasma glucose concentrations were greater (P0.02) in CC vs. RCC and RT on day 7. Plasma concentrations of nonesterified fatty acids were greater (P0.02) in RT and RCC vs. CC on day 7, and in RT vs. CC on day 17. Steers receiving the synbiotic supplement had improved response to BRD treatment, suggesting heightened immunocompetence from partially enhanced metabolism and the nutraceutical effects of B. subtilis and yeast compounds.

published proceedings

  • Animal

altmetric score

  • 2.75

author list (cited authors)

  • Colombo, E. A., Cooke, R. F., Brando, A. P., Wiegand, J. B., Schubach, K. M., Sowers, C. A., ... Gouva, V. N.

citation count

  • 9

complete list of authors

  • Colombo, EA||Cooke, RF||Brandão, AP||Wiegand, JB||Schubach, KM||Sowers, CA||Duff, GC||Block, E||Gouvêa, VN

publication date

  • January 2021

published in