Organ-specific, multimodal, wireless optoelectronics for high-throughput phenotyping of peripheral neural pathways.
Academic Article
Overview
Research
Identity
Additional Document Info
Other
View All
Overview
abstract
The vagus nerve supports diverse autonomic functions and behaviors important for health and survival. To understand how specific components of the vagus contribute to behaviors and long-term physiological effects, it is critical to modulate their activity with anatomical specificity in awake, freely behaving conditions using reliable methods. Here, we introduce an organ-specific scalable, multimodal, wireless optoelectronic device for precise and chronic optogenetic manipulations in vivo. When combined with an advanced, coil-antenna system and a multiplexing strategy for powering 8 individual homecages using a single RF transmitter, the proposed wireless telemetry enables low cost, high-throughput, and precise functional mapping of peripheral neural circuits, including long-term behavioral and physiological measurements. Deployment of these technologies reveals an unexpected role for stomach, non-stretch vagal sensory fibers in suppressing appetite and demonstrates the durability of the miniature wireless device inside harsh gastric conditions.
published proceedings
Nat Commun
altmetric score
126.24
author list (cited authors)
Kim, W. S., Hong, S., Gamero, M., Jeevakumar, V., Smithhart, C. M., Price, T. J., ... Park, S. I.
citation count
21
complete list of authors
Kim, Woo Seok||Hong, Sungcheol||Gamero, Milenka||Jeevakumar, Vivekanand||Smithhart, Clay M||Price, Theodore J||Palmiter, Richard D||Campos, Carlos||Park, Sung Il
