Organ-specific, multimodal, wireless optoelectronics for high-throughput phenotyping of peripheral neural pathways. Academic Article uri icon


  • The vagus nerve supports diverse autonomic functions and behaviors important for health and survival. To understand how specific components of the vagus contribute to behaviors and long-term physiological effects, it is critical to modulate their activity with anatomical specificity in awake, freely behaving conditions using reliable methods. Here, we introduce an organ-specific scalable, multimodal, wireless optoelectronic device for precise and chronic optogenetic manipulations in vivo. When combined with an advanced, coil-antenna system and a multiplexing strategy for powering 8 individual homecages using a single RF transmitter, the proposed wireless telemetry enables low cost, high-throughput, and precise functional mapping of peripheral neural circuits, including long-term behavioral and physiological measurements. Deployment of these technologies reveals an unexpected role for stomach, non-stretch vagal sensory fibers in suppressing appetite and demonstrates the durability of the miniature wireless device inside harsh gastric conditions.

published proceedings

  • Nat Commun

altmetric score

  • 126.24

author list (cited authors)

  • Kim, W. S., Hong, S., Gamero, M., Jeevakumar, V., Smithhart, C. M., Price, T. J., ... Park, S. I.

citation count

  • 21

complete list of authors

  • Kim, Woo Seok||Hong, Sungcheol||Gamero, Milenka||Jeevakumar, Vivekanand||Smithhart, Clay M||Price, Theodore J||Palmiter, Richard D||Campos, Carlos||Park, Sung Il

publication date

  • January 2021