The ubiquitous transcriptional protein ZNF143 activates a diversity of genes while assisting to organize chromatin structure. Academic Article

abstract

• Zinc Finger Protein 143 (ZNF143) is a pervasive C2H2 zinc-finger transcriptional activator protein regulating the efficiency of eukaryotic promoter regions. ZNF143 is able to activate transcription at both protein coding genes and small RNA genes transcribed by either RNA polymerase II or RNA polymerase III. Target genes regulated by ZNF143 are involved in an array of different cellular processes including both cancer and development. Although a key player in regulating eukaryotic genes, the molecular mechanism by with ZNF143 binds and activates genes transcribed by two different polymerases is still relatively unknown. In addition to its role as a transcriptional regulator, recent genomics experiments have implicated ZNF143 as a potential co-factor involved in chromatin looping and establishing higher order structure within the genome. This review focuses primarily on possible activation mechanisms of promoters by ZNF143, with less emphasis on the role of ZNF143 in cancer and development, and its function in establishing higher order chromatin contacts within the genome.

authors

• Kunkel, Gary

published proceedings

• Gene

altmetric score

• 1

author list (cited authors)

• Huning, L., & Kunkel, G. R.

citation count

• 5

complete list of authors

• Huning, Laura||Kunkel, Gary R

publication date

• January 2021

publisher

• Elsevier  Publisher

published in

• Gene  Journal

keywords

• Animals
• Chromatin
• Chromatin Looping
• Eukaryotic Transcriptional Activation
• Gene Expression Regulation
• Gene Regulation
• Humans
• Molecular Structure
• Trans-Activators
• Transcription Factors

Digital Object Identifier (DOI)

• 10.1016/j.gene.2020.145205

start page

• 145205

end page

• 145205

volume

• 769

URL

• http://dx.doi.org/10.1016/j.gene.2020.145205