The vital role of Gli1+ mesenchymal stem cells in tissue development and homeostasis. Academic Article

abstract

• The hedgehog (Hh) signaling pathway plays an essential role in both tissue development and homeostasis. Glioma-associated oncogene homolog 1 (Gli1) is one of the vital transcriptional factors as well as the direct target gene in the Hh signaling pathway. The cells expressing theGli1 gene (Gli1+ cells) have been identified as mesenchymal stem cells (MSCs) that are responsible for various tissue developments, homeostasis, and injury repair. This review outlines some recent discoveries on the crucial roles of Gli1+ MSCs in the development and homeostasis of varieties of hard and soft tissues.

authors

• Feng, Jian

published proceedings

• J Cell Physiol

author list (cited authors)

• Jing, D., Li, C., Yao, K. e., Xie, X., Wang, P., Zhao, H. u., ... Wang, J.

citation count

• 4

complete list of authors

• Jing, Dian||Li, Chaoyuan||Yao, Ke||Xie, Xudong||Wang, Peiqi||Zhao, Hu||Feng, Jian Q||Zhao, Zhihe||Wu, Yafei||Wang, Jun

publication date

• September 2021

publisher

• Wiley  Publisher

published in

• Journal of Cellular Physiology  Journal

keywords

• Animals
• Development
• Gli1
• Hedgehog Proteins
• Hedgehog Signaling
• Homeostasis
• Humans
• Mesenchymal Stem Cells
• Organogenesis
• Signal Transduction
• Zinc Finger Protein GLI1

PubMed Central ID

• 33533019

Digital Object Identifier (DOI)

• 10.1002/jcp.30310

start page

• 6077

end page

• 6089

volume

• 236

issue

• 9

URL

• http://dx.doi.org/10.1002/jcp.30310