Multi-omic analyses in Abyssinian cats with primary renal amyloid deposits. Academic Article uri icon


  • The amyloidoses constitute a group of diseases occurring in humans and animals that are characterized by abnormal deposits of aggregated proteins in organs, affecting their structure and function. In the Abyssinian cat breed, a familial form of renal amyloidosis has been described. In this study, multi-omics analyses were applied and integrated to explore some aspects of the unknown pathogenetic processes in cats. Whole-genome sequences of two affected Abyssinians and 195 controls of other breeds (part of the 99 Lives initiative) were screened to prioritize potential disease-associated variants. Proteome and miRNAome from formalin-fixed paraffin-embedded kidney specimens of fully necropsied Abyssinian cats, three affected and three non-amyloidosis-affected were characterized. While the trigger of the disorder remains unclear, overall, (i) 35,960 genomic variants were detected; (ii) 215 and 56 proteins were identified as exclusive or overexpressed in the affected and control kidneys, respectively; (iii) 60 miRNAs were differentially expressed, 20 of which are newly described. With omics data integration, the general conclusions are: (i) the familial amyloid renal form in Abyssinians is not a simple monogenic trait; (ii) amyloid deposition is not triggered by mutated amyloidogenic proteins but is a mix of proteins codified by wild-type genes; (iii) the form is biochemically classifiable as AA amyloidosis.

published proceedings

  • Sci Rep

altmetric score

  • 1.5

author list (cited authors)

  • Genova, F., Nonnis, S., Maffioli, E., Tedeschi, G., Strillacci, M. G., Carisetti, M., ... Longeri, M.

citation count

  • 1

complete list of authors

  • Genova, Francesca||Nonnis, Simona||Maffioli, Elisa||Tedeschi, Gabriella||Strillacci, Maria Giuseppina||Carisetti, Michela||Sironi, Giuseppe||Cupaioli, Francesca Anna||Di Nanni, Noemi||Mezzelani, Alessandra||Mosca, Ettore||Helps, Christopher R||Leegwater, Peter AJ||Dorso, Laetitia||Longeri, Maria

publication date

  • January 2021