HER2 Overexpression and Amplification in Feline Pulmonary Carcinoma Academic Article uri icon

abstract

  • HER2 is overexpressed, amplified, and mutated in a subset of human lung cancer. The aim of this study was to investigate HER2 protein overexpression and gene amplification in feline pulmonary carcinomas. Thirteen pulmonary carcinomas were selected and TTF-1 and HER2 expression was evaluated by immunohistochemistry. Fluorescence in situ hybridization (FISH) was performed with a HER2 probe and a BAC probe for the feline chromosome E1p1.12-p1.11 region. Twelve adenocarcinomas and 1 squamous cell carcinoma were diagnosed. TTF-1 was positive in 7 carcinomas (58%). HER2 was overexpressed in 2 (15%), equivocal in 5 (38%), and negative in 6 cases (46%). FISH analysis of HER2 was indeterminate in 2 cases. Three pulmonary carcinomas (27%) had HER2 amplification and 8 cases were not amplified (73%). The significant correlation between HER2 protein overexpression and gene amplification are promising preliminary data, but study of additional cases is needed to confirm HER2 as a target for possible innovative treatments.

author list (cited authors)

  • Muscatello, L. V., Di Oto, E., Dignazzi, M., Murphy, W. J., Porcellato, I., De Maria, R., ... Brunetti, B.

complete list of authors

  • Muscatello, Luisa Vera||Oto, Enrico Di||Dignazzi, Miriam||Murphy, William J||Porcellato, Ilaria||De Maria, Raffaella||Raudsepp, Terje||Foschini, Maria Pia||Sforna, Monica||Benazzi, Cinzia||Brunetti, Barbara

publication date

  • January 1, 2021 11:11 AM