Coherent anti-Stokes Raman scattering microspectroscopy: an emerging technique for non-invasive optical assessment of a local bio-nano-environment. Academic Article uri icon


  • Raman spectroscopy provides a non-invasive, chemically-specific optical imaging of biological objects without relying on endogenous labels. Nonlinear Raman spectroscopy allows non-invasive imaging at much faster speed with an improved spatial resolution and axial sectioning capability. In this report we propose a novel use of nonlinear Raman spectroscopy as a sensor of local nano-environment. Time-resolved coherent anti-Stokes Raman spectrograms are found to be sensitive to small variations of local structural changes, which are not normally observed using conventional Raman spectroscopy.

published proceedings

  • IEEE J Sel Top Quantum Electron

author list (cited authors)

  • Shutov, A. D., Harrington, J. T., Zhu, H., Wang, D., Zhang, D., & Yakovlev, V. V.

citation count

  • 1

complete list of authors

  • Shutov, Anton D||Harrington, Joseph T||Zhu, Hanlin||Wang, Da-Wei||Zhang, Delong||Yakovlev, Vladislav V

publication date

  • September 2021