Methods for the Manipulation of Herpesvirus Genome and the Application to Marek's Disease Virus Research. Academic Article

abstract

• Herpesviruses are a group of double-strand DNA viruses that infect a wide range of hosts, including humans and animals. In the past decades, numerous methods have been developed to manipulate herpesviruses genomes, from the introduction of random mutations to specific genome editing. The development of genome manipulation methods has largely advanced the study of viral genes function, contributing not only to the understanding of herpesvirus biology and pathogenesis, but also the generation of novel vaccines and therapies to control and treat diseases. In this review, we summarize the major methods of herpesvirus genome manipulation with emphasis in their application to Marek's disease virus research.

authors

• Lupiani, Blanca
• Reddy, Sanjay

published proceedings

• Microorganisms

author list (cited authors)

• Liao, Y., Bajwa, K., Reddy, S. M., & Lupiani, B.

citation count

• 0

complete list of authors

• Liao, Yifei||Bajwa, Kanika||Reddy, Sanjay M||Lupiani, Blanca

publication date

• January 2021

publisher

• MDPI  Publisher

published in

• Microorganisms  Journal

keywords

• Genome Manipulation
• Herpesvirus
• Marek’s Disease Virus
• Pathogenesis

PubMed Central ID

• 34200544

Digital Object Identifier (DOI)

• 10.3390/microorganisms9061260

start page

• 1260

end page

• 1260

volume

• 9

issue

• 6

URL

• http://dx.doi.org/10.3390/microorganisms9061260