Latest Insights into Unique Open Reading Frames Encoded by Unique Long (UL) and Short (US) Regions of Marek's Disease Virus.

abstract

• Marek's disease virus (MDV) is an oncogenic avian alphaherpesvirus whose genome consists of unique long (UL) and short (US) regions that are flanked by inverted repeat regions. More than 100 open reading frames (ORFs) have been annotated in the MDV genome, and are involved in various aspects of MDV biology and pathogenesis. Within UL and US regions of MDV, there are several unique ORFs, some of which have recently been shown to be important for MDV replication and pathogenesis. In this review, we will summarize the current knowledge on these ORFs and compare their location in different MDV strains.

authors

• Lupiani, Blanca
• Reddy, Sanjay

published proceedings

• Viruses

author list (cited authors)

• Liao, Y., Lupiani, B., & Reddy, S. M.

citation count

• 1

complete list of authors

• Liao, Yifei||Lupiani, Blanca||Reddy, Sanjay M

publication date

• January 2021

publisher

• MDPI  Publisher

published in

• Viruses  Journal

keywords

• Animals
• Chickens
• DNA, Viral
• Genome
• Genome, Viral
• Herpesvirus 2, Gallid
• Marek Disease
• Marek’s Disease Virus
• Open Reading Frame
• Open Reading Frames
• Pathogenesis
• Replication
• Viral Proteins
• Virus Replication

Digital Object Identifier (DOI)

• 10.3390/v13060974

start page

• 974

end page

• 974

volume

• 13

issue

• 6

URL

• http://dx.doi.org/10.3390/v13060974