SelfAssembled Peptide NanoSuperstructure towards Enzyme Mimicking Hydrolysis Academic Article uri icon


  • AbstractThe structural arrangement of amino acid residues in native enzymes underlies their remarkable catalytic properties, thus providing a notable point of reference for designing potent yet simple biomimetic catalysts. Herein, we describe a minimalistic approach to construct a dipeptidebased nanosuperstructure with enzymelike activity. The selfassembled biocatalyst comprises one peptide as a single building block, readily synthesized from histidine. Through coordination with zinc ion, the peptide selfassembly procedure allows the formation of supramolecular sheet ordered nanocrystals, which can be used as basic units to further construct higherorder superstructure. As a result, remarkable hydrolysis activity and enduring stability are demonstrated. Our work exemplifies the use of a bioinspired supramolecular assembly approach to develop nextgeneration biocatalysts for biotechnological applications.

published proceedings

  • Angewandte Chemie

author list (cited authors)

  • Chen, Y. u., Yang, Y., Orr, A. A., Makam, P., Redko, B., Haimov, E., ... Gazit, E.

citation count

  • 11

complete list of authors

  • Chen, Yu||Yang, Yuqin||Orr, Asuka A||Makam, Pandeeswar||Redko, Boris||Haimov, Elvira||Wang, Yannan||Shimon, Linda JW||Rencusā€Lazar, Sigal||Ju, Meiting||Tamamis, Phanourios||Dong, Hao||Gazit, Ehud

publication date

  • July 2021