Engineering Supramolecular Organizing Centers for Optogenetic Control of Innate Immune Responses. Academic Article

abstract

• The spatiotemporal organization of oligomeric protein complexes, such as the supramolecular organizing centers (SMOCs) made of MyDDosome and MAVSome, is essential for transcriptional activation of host inflammatory responses and immunometabolism. Light-inducible assembly of MyDDosome and MAVSome is presented herein to induce activation of nuclear factor-kB and type-I interferons. Engineering of SMOCs and the downstream transcription factor permits programmable and customized innate immune operations in a light-dependent manner. These synthetic molecular tools will likely enable optical and user-defined modulation of innate immunity at a high spatiotemporal resolution to facilitate mechanistic studies of distinct modes of innate immune activations and potential intervention of immune disorders and cancer.

authors

• Zhou, Yubin

published proceedings

• Adv Biol (Weinh)

altmetric score

• 2.35

author list (cited authors)

• Tan, P., He, L., & Zhou, Y.

citation count

• 1

complete list of authors

• Tan, Peng||He, Lian||Zhou, Yubin

publication date

• May 2021

publisher

• Wiley  Publisher

published in

• Advanced Biology  Journal

keywords

• Immunity, Innate
• Innate Immunity
• Optogenetics
• Signal Transduction
• Synthetic Biology

PubMed Central ID

• 34028210

Digital Object Identifier (DOI)

• 10.1002/adbi.202000147

start page

• e2000147

end page

• 2000147

volume

• 5

issue

• 5

URL

• http://dx.doi.org/10.1002/adbi.202000147