Self-Assembled Peptide Nano-Superstructure towards Enzyme Mimicking Hydrolysis. Academic Article uri icon


  • The structural arrangement of amino acid residues in native enzymes underlies their remarkable catalytic properties, thus providing a notable point of reference for designing potent yet simple biomimetic catalysts. Herein, we describe a minimalistic approach to construct a dipeptide-based nano-superstructure with enzyme-like activity. The self-assembled biocatalyst comprises one peptide as a single building block, readily synthesized from histidine. Through coordination with zinc ion, the peptide self-assembly procedure allows the formation of supramolecular -sheet ordered nanocrystals, which can be used as basic units to further construct higher-order superstructure. As a result, remarkable hydrolysis activity and enduring stability are demonstrated. Our work exemplifies the use of a bioinspired supramolecular assembly approach to develop next-generation biocatalysts for biotechnological applications.

published proceedings

  • Angew Chem Int Ed Engl

altmetric score

  • 2.6

author list (cited authors)

  • Chen, Y. u., Yang, Y., Orr, A. A., Makam, P., Redko, B., Haimov, E., ... Gazit, E.

citation count

  • 12

complete list of authors

  • Chen, Yu||Yang, Yuqin||Orr, Asuka A||Makam, Pandeeswar||Redko, Boris||Haimov, Elvira||Wang, Yannan||Shimon, Linda JW||Rencus-Lazar, Sigal||Ju, Meiting||Tamamis, Phanourios||Dong, Hao||Gazit, Ehud

publication date

  • July 2021