Assessment of Toxicity of Nanoparticles Using Insects as Biological Models. Chapter uri icon

abstract

  • Nanomaterials have become increasingly important in medicine, manufacturing, and consumer products. A fundamental understanding of the effects of nanoparticles (NPs) and their interactions with biomolecules and organismal systems has yet to be achieved. In this chapter, we firstly provide a brief review of the interactions between nanoparticles and biological systems. We then provide an example by describing a novel method to assess the effects of NPs on biological systems, using insects as a model. Nanoparticles were injected into the central nervous system of the discoid cockroach (Blaberus discoidalis). It was found that insects became hyperactive compared to negative control (water injections). Our method could provide a generic method of assessing nanoparticles toxicity.

author list (cited authors)

  • Zhou, Y., Chen, Y., Rocha, A., Sanchez, C. J., & Liang, H.

citation count

  • 1

complete list of authors

  • Zhou, Yan||Chen, Yan||Rocha, Aracely||Sanchez, Carlos J||Liang, Hong

Book Title

  • Methods in Molecular Biology

publication date

  • March 2020