Assessment of Toxicity of Nanoparticles Using Insects as Biological Models. Chapter

abstract

• Nanomaterials have become increasingly important in medicine, manufacturing, and consumer products. A fundamental understanding of the effects of nanoparticles (NPs) and their interactions with biomolecules and organismal systems has yet to be achieved. In this chapter, we firstly provide a brief review of the interactions between nanoparticles and biological systems. We then provide an example by describing a novel method to assess the effects of NPs on biological systems, using insects as a model. Nanoparticles were injected into the central nervous system of the discoid cockroach (Blaberus discoidalis). It was found that insects became hyperactive compared to negative control (water injections). Our method could provide a generic method of assessing nanoparticles toxicity.

authors

• Liang, Hong

author list (cited authors)

• Zhou, Y., Chen, Y., Rocha, A., Sanchez, C. J., & Liang, H.

citation count

• 1

complete list of authors

• Zhou, Yan||Chen, Yan||Rocha, Aracely||Sanchez, Carlos J||Liang, Hong

Book Title

• NANOPARTICLES IN BIOLOGY AND MEDICINE, 2 EDITION

publication date

• January 2020

publisher

• Springer Nature  Publisher

published in

• Methods in molecular biology (Clifton, N.J.)  Journal

keywords

• Animals
• Central Nervous System
• Cockroach Walking Distance
• Cockroaches
• Female
• Insects
• Magnetic Nanoparticles
• Male
• Models, Animal
• Motor Activity
• Nanomaterials
• Nanoparticles
• Nervous System
• Toxicity

PubMed Central ID

• 32152986

Digital Object Identifier (DOI)

• 10.1007/978-1-0716-0319-2_20

International Standard Book Number (ISBN) 13

• 978-1-0716-0318-5

start page

• 269

end page

• 279

volume

• 2118

URL

• http://dx.doi.org/10.1007/978-1-0716-0319-2_20