Increased reactivity to histamine in the coronary vascular system of the guinea-pig after endotoxin. Academic Article

abstract

• Histamine produced a dose-dependent increase in heart rate, myocardial contractility and coronary flow in the isolated guinea-pig heart using a modified Langendorff procedure. Intraperitoneal treatment of the guinea pigs with E. coli endotoxin, 4 days prior to the experiment, enhanced the positive chronotropic and flow-increasing effect of histamine. The increased response to histamine appeared to be H1-receptor mediated, the positive chronotropic response is attributed to H2-receptors. These results indicate that bacterial endotoxin increases the reactivity of the coronary vascular system of the guinea-pig to histamine.

authors

• Ten Have, Gabriella

published proceedings

• Agents Actions

author list (cited authors)

• van Heuven-Nolsen, D., Ten Have, G. A., & Nijkamp, F. P.

citation count

• 1

publication date

• April 1989

publisher

• Springer Nature  Publisher

keywords

• Animals
• Coronary Circulation
• Endotoxins
• Guinea Pigs
• Heart Rate
• Histamine
• Male
• Myocardial Contraction
• Receptors, Histamine

PubMed Central ID

• 2750587

Digital Object Identifier (DOI)

• 10.1007/BF02222226

start page

• 158

end page

• 159

volume

• 27

issue

• 1-2

URL

• http://dx.doi.org/10.1007/bf02222226