Targeting NF-B-Inducing Kinase (NIK) in Immunity, Inflammation, and Cancer. Academic Article

abstract

• NF-B-inducing kinase (NIK), the essential upstream kinase, which regulates activation of the noncanonical NF-B pathway, has important roles in regulating immunity and inflammation. In addition, NIK is vital for maintaining cellular health through its control of fundamental cellular processes, including differentiation, growth, and cell survival. As such aberrant expression or regulation of NIK is associated with several disease states. For example, loss of NIK leads to severe immune defects, while the overexpression of NIK is observed in inflammatory diseases, metabolic disorders, and the development and progression of cancer. This review discusses recent studies investigating the therapeutic potential of NIK inhibitors in various diseases.

authors

• Sitcheran, Raquel

published proceedings

• Int J Mol Sci

author list (cited authors)

• Pflug, K. M., & Sitcheran, R.

citation count

• 32

complete list of authors

• Pflug, Kathryn M||Sitcheran, Raquel

publication date

• November 2020

publisher

• MDPI  Publisher

published in

• International Journal of Molecular Sciences  Journal

keywords

• Animals
• Cancer
• Cell Survival
• Humans
• Immunity
• Inflammation
• Inflammatory Disease
• MAP3K14
• NF-kappa B
• NIK
• Neoplasms
• Nf-κb
• Nf-κb-inducing Kinase
• Protein Serine-threonine Kinases
• Signal Transduction
• Small-molecule Inhibitors
• Therapeutics

PubMed Central ID

• 33187137

Digital Object Identifier (DOI)

• 10.3390/ijms21228470

start page

• 8470

end page

• 8470

volume

• 21

issue

• 22

URL

• http://dx.doi.org/10.3390/ijms21228470