Hemoglobin A1c improvements and better diabetes-specific quality of life among participants completing diabetes self-management programs: a nested cohort study. Academic Article uri icon


  • BACKGROUND: Numerous primary care innovations emphasize patient-centered processes of care. Within the context of these innovations, greater understanding is needed of the relationship between improvements in clinical endpoints and patient-centered outcomes. To address this gap, we evaluated the association between glycosylated hemoglobin (HbA1c) and diabetes-specific quality of life among patients completing diabetes self-management programs. METHODS: We conducted a retrospective cohort study nested within a randomized comparative effectiveness trial of diabetes self-management interventions in 75 diabetic patients. Multiple linear regression models were developed to examine the relationship between change in HbA1c from baseline to one-year follow-up and Diabetes-39 (a diabetes-specific quality of life measure) at one year. RESULTS: HbA1c levels improved for the overall cohort from baseline to one-year follow-up (t (74)=3.09, p=.0029). One-year follow up HbA1c was correlated with worse overall quality of life (r=0.33, p=0.004). Improvements in HbA1c from baseline to one-year follow-up were associated with greater D-39 diabetes control ( = 0.23, p=.04) and D-39 sexual functioning ( = 0.25, p=.03) quality of life subscales. CONCLUSIONS: Improvements in HbA1c among participants completing a diabetes self-management program were associated with better diabetes-specific quality of life. Innovations in primary care that engage patients in self-management and improve clinical biomarkers, such as HbA1c, may also be associated with better quality of life, a key outcome from the patient perspective.

published proceedings

  • Health Qual Life Outcomes

altmetric score

  • 1.35

author list (cited authors)

  • Khanna, A., Bush, A. L., Swint, J. M., Peskin, M. F., Street, R. L., & Naik, A. D.

citation count

  • 36

complete list of authors

  • Khanna, Abhinav||Bush, Amber L||Swint, J Michael||Peskin, Melissa Fleschler||Street, Richard L||Naik, Aanand D

publication date

  • May 2012