At the junction of SNARE and SM protein function. Academic Article

abstract

• Sec1/Munc18 (SM) proteins bind to and function with soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) at each vesicle fusion site in the cell. The purpose for these interactions is becoming clearer, as what had been interpreted as functional divergence between SM proteins acting at different vesicle trafficking steps, or in specialized cells, is giving way to more recent evidence for common functions among all SM proteins. What is emerging is a picture of SM proteins acting not merely as SNARE regulators, but also as central components of the membrane fusion apparatus. The available data suggest sequential models that describe how the soluble SM protein might first regulate SNARE complex assembly and then cooperate with SNAREs to stimulate membrane fusion.

authors

• Carr, Chavela

published proceedings

• Curr Opin Cell Biol

altmetric score

• 0.25

author list (cited authors)

• Carr, C. M., & Rizo, J.

citation count

• 142

complete list of authors

• Carr, Chavela M||Rizo, Josep

publication date

• August 2010

publisher

• Elsevier  Publisher

published in

• Current Opinion in Cell Biology  Journal

keywords

• Animals
• Humans
• Membrane Fusion
• Models, Biological
• Munc18 Proteins
• Protein Binding
• Qa-SNARE Proteins
• Snare Proteins

Digital Object Identifier (DOI)

• 10.1016/j.ceb.2010.04.006

start page

• 488

end page

• 495

volume

• 22

issue

• 4

URL

• http://dx.doi.org/10.1016/j.ceb.2010.04.006