Enhanced Osteogenic Potential of Phosphonated-Siloxane Hydrogel Scaffolds. Academic Article uri icon


  • In a material-guided approach, instructive scaffolds that leverage potent chemistries may efficiently promote bone regeneration. A siloxane macromer has been previously shown to impart osteoinductivity and bioactivity when included in poly(ethylene glycol) diacrylate (PEG-DA) hydrogel scaffolds. Herein, phosphonated-siloxane macromers were evaluated for enhancing the osteogenic potential of siloxane-containing PEG-DA scaffolds. Two macromers were prepared with different phosphonate pendant group concentrations, poly(diethyl(2-(propylthio)ethyl)phosphonate methylsiloxane) diacrylate (PPMS-DA) and 25%-phosphonated analogue (PPMS-DA 25%). Macroporous, templated scaffolds were prepared by cross-linking these macromers with PEG-DA at varying mol % (15:85, 30:70, and 45:55 PPMS-DA to PEG-DA; 30:70 PPMS-DA 25% to PEG-DA). Other scaffolds were also prepared by combining PEG-DA with PDMS-MA (i.e., no phosphonate) or with vinyl phosphonate (i.e., no siloxane). Scaffold material properties were thoroughly assessed, including pore morphology, hydrophobicity, swelling, modulus, and bioactivity. Scaffolds were cultured with human bone marrow-derived mesenchymal stem cells (normal media) and calcium deposition and protein expression were assessed at 14 and 28 days.

published proceedings

  • Biomacromolecules

altmetric score

  • 2

author list (cited authors)

  • Frassica, M. T., Jones, S. K., Suriboot, J., Arabiyat, A. S., Ramirez, E. M., Culibrk, R. A., Hahn, M. S., & Grunlan, M. A.

citation count

  • 5

complete list of authors

  • Frassica, Michael T||Jones, Sarah K||Suriboot, Jakkrit||Arabiyat, Ahmad S||Ramirez, Esteban M||Culibrk, Robert A||Hahn, Mariah S||Grunlan, Melissa A

publication date

  • December 2020