A rhesus macaque radiation hybrid map and comparative analysis with the human genome. Academic Article

abstract

• The genomes of nonhuman primates are powerful references for better understanding the recent evolution of the human genome. Here we compare the order of 802 genomic markers mapped in a rhesus macaque (Macaca mulatta) radiation hybrid panel with the human genome, allowing for nearly complete cross-reference to the human genome at an average resolution of 3.5 Mb. At least 23 large-scale chromosomal rearrangements, mostly inversions, are needed to explain the changes in marker order between human and macaque. Analysis of the breakpoints flanking inverted chromosomal segments and estimation of their duplication divergence dates provide additional evidence implicating segmental duplications as a major mechanism of chromosomal rearrangement in recent primate evolution.

authors

• Murphy, William

published proceedings

• Genomics

author list (cited authors)

• Murphy, W. J., Agarwala, R., Schffer, A. A., Stephens, R., Smith, C., Crumpler, N. J., David, V. A., & O'Brien, S. J.

citation count

• 31

complete list of authors

• Murphy, William J||Agarwala, Richa||Schäffer, Alejandro A||Stephens, Robert||Smith, Clarence||Crumpler, Nicole J||David, Victor A||O'Brien, Stephen J

publication date

• January 2005

publisher

• Elsevier  Publisher

published in

• Genomics  Journal

keywords

• Animals
• CHROMOSOME BREAKAGE
• Chromosomes
• Evolution, Molecular
• Genome, Human
• Humans
• Macaca Mulatta
• Radiation Hybrid Mapping
• Synteny

Digital Object Identifier (DOI)

• 10.1016/j.ygeno.2005.05.013

start page

• 383

end page

• 395

volume

• 86

issue

• 4

URL

• http://dx.doi.org/10.1016/j.ygeno.2005.05.013