A significant portion of both fatal and total crashes occurs at intersections in the United States. Skew angle may be a significant contributor to these crashes. This paper examines the effects of intersection angle on intersection safety performance. With seven years of crash data from Minnesota and five years of crash data from Ohio, random forest regression data mining and negative binomial regression models were developed to estimate crash modification functions at three-leg and four-leg stop-controlled intersections with two-lane and multilane major legs. Where possible, the results were compared between the two states and used to develop average crash modification function curves. This study shows that over half of the intersection types experience the highest number of predicted crashes when the intersection angle between roadway legs is between 50 degrees and 65 degrees. These results have practical implications for engineers and safety professionals. First, the crash modification function curves supplement and revise the guidance for intersection angle in the Highway Safety Manual and Policy on Geometric Design of Highways and Streets. Second, the functions offer new guidance to agencies planning intersection improvements. Third, the crash modification functions can be used to determine the safety effect of changes in intersection angle.