PROTAC Compatibilities, Degrading Cell‐Surface Receptors, and the Sticky Problem of Finding a Molecular Glue Academic Article uri icon

abstract

  • PROteolysis TArgeting Chimeras (PROTACs) are emerging as critical tools in biomedicinal chemistry and drug design, but they have limitations. These limitations include a lack of guiding principles when selecting suitable E3 ligases to induce ubiquitinylation, and problems degrading cell-surface receptors. This Highlight outlines some recent advances that circumvent some of these limitations, and new alternative methods to induce selective protein degradation.

altmetric score

  • 9.2

author list (cited authors)

  • Tian, C., & Burgess, K.

citation count

  • 0

publication date

  • October 2020

publisher