PROTAC Compatibilities, Degrading Cell-Surface Receptors, and the Sticky Problem of Finding a Molecular Glue. Academic Article

abstract

• PROteolysis TArgeting Chimeras (PROTACs) are emerging as critical tools in biomedicinal chemistry and drug design, but they have limitations. These limitations include a lack of guiding principles when selecting suitable E3 ligases to induce ubiquitinylation, and problems degrading cell-surface receptors. This Highlight outlines some recent advances that circumvent some of these limitations, and new alternative methods to induce selective protein degradation.

authors

• Burgess, Kevin

published proceedings

• ChemMedChem

altmetric score

• 12.2

author list (cited authors)

• Tian, C., & Burgess, K.

citation count

• 2

complete list of authors

• Tian, Conghe||Burgess, Kevin

publication date

• January 2021

publisher

• Wiley  Publisher

published in

• ChemMedChem: chemistry enabling drug discovery  Journal

keywords

• Data Mining
• Humans
• Lytacs
• Mab Conjugate
• Native Mass Spectrometry
• Protacs
• Receptors, Cell Surface
• Ubiquitin-Protein Ligases
• Ubiquitination

PubMed Central ID

• 33112038

Digital Object Identifier (DOI)

• 10.1002/cmdc.202000683

start page

• 316

end page

• 318

volume

• 16

issue

• 2

URL

• http://dx.doi.org/10.1002/cmdc.202000683