Bariatric Radioembolization: A Pilot Study on Technical Feasibility and Safety in a Porcine Model.
- Additional Document Info
- View All
PURPOSE: To evaluate feasibility of left gastric artery (LGA) yttrium-90 ((90)Y) radioembolization as potential treatment for obesity in a porcine model. MATERIALS AND METHODS: This study included 8 young female pigs (12-13 weeks, 21.8-28.1 kg). Six animals received infusions of (90)Y resin microspheres (46.3-105.1 MBq) into the main LGA and the gastric artery arising from the splenic artery. Animal weight and serum ghrelin were measured before treatment and weekly thereafter. Animals were euthanized 69-74 days after treatment, and histologic analyses of mucosal integrity and ghrelin immunoreactive cell density were performed. RESULTS: Superficial mucosal ulcerations < 3.0 cm(2) were noted in 5 of 6 treated animals. Ghrelin immunoreactive cell density was significantly lower in treated versus untreated animals in the stomach fundus (13.5 vs 34.8, P < .05) and stomach body (11.2 vs 19.8, P < .05). Treated animals gained less weight than untreated animals over the study duration (40.2 kg 5.4 vs 54.7 kg 6.5, P = .053). Average fundic parietal area (165 cm(2) vs 282 cm(2), P = .067) and average stomach weight (297.2 g vs 397.0 g, P = .067) were decreased in treated versus untreated animals. Trichrome staining revealed significantly more fibrosis in treatment animals compared with control animals (13.0 vs 8.6, P < .05). No significant differences were identified in plasma ghrelin concentrations (P = .24). CONCLUSIONS: LGA (90)Y radioembolization is promising as a potential treatment for obesity. A larger preclinical study is needed to evaluate the safety and efficacy of this procedure further.
author list (cited authors)
Pasciak, A. S., Bourgeois, A. C., Paxton, B. E., Nodit, L., Coan, P. N., Kraitchman, D., ... Bradley, Y. C.
complete list of authors
Pasciak, Alexander S||Bourgeois, Austin C||Paxton, Ben E||Nodit, Laurentia||Coan, Patricia N||Kraitchman, Dara||Stinnett, Sandra S||Patel, Vijay M||Fu, Yingli||Adams, Joleen K||Tolbert, M Katherine||Lux, Cassie N||Arepally, Aravind||Bradley, Yong C