Transarterial Delivery of a Biodegradable Single-Agent Theranostic Nanoprobe for Liver Tumor Imaging and Combinatorial Phototherapy. Academic Article uri icon


  • PURPOSE: To assess selective accumulation of biodegradable nanoparticles within hepatic tumors after transarterial delivery for invivo localization and combinatorial phototherapy. MATERIALS AND METHODS: A VX2 hepatic tumor model was used in New Zealand white rabbits. Transarterial delivery of silicon naphthalocyanine biodegradable nanoparticles was performed using a microcatheter via the proper hepatic artery. Tumors were exposed via laparotomy, and nanoparticles were observed by near-infrared (NIR) fluorescence imaging. For phototherapy, a handheld NIR laser (785 nm) at 0.6 W/cm2 was used to expose tumor or background liver, and tissue temperatures were assessed with a fiberoptic temperature probe. Intratumoral reactive oxygen species formation was assessed using a fluorophore (2',7'-dichlorodihydrofluorescein diacetate). RESULTS: Nanoparticles selectively accumulated within viable tumor by NIR fluorescence. Necrotic portions of tumor did not accumulate nanoparticles, consistent with a vascular distribution. NIR-dependent heat generation was observed with nanoparticle-containing tumors, but not in background liver. No heat was generated in the absence of NIR laser light. Reactive oxygen species were formed in nanoparticle-containing tumors exposed to NIR laser light, but not in background liver treated with NIR laser or in tumors in the absence of NIR light. CONCLUSIONS: Biodegradable nanoparticle delivery to liver tumors from a transarterial approach enabled selective invivo tumor imaging and combinatorial phototherapy.

published proceedings

  • J Vasc Interv Radiol

altmetric score

  • 2.25

author list (cited authors)

  • Taratula, O. R., Taratula, O., Han, X., Jahangiri, Y., Tomozawa, Y., Horikawa, M., ... Farsad, K.

citation count

  • 6

complete list of authors

  • Taratula, Olena R||Taratula, Oleh||Han, Xiangjun||Jahangiri, Younes||Tomozawa, Yuki||Horikawa, Masahiro||Uchida, Barry||Albarqi, Hassan A||Schumann, Canan||Bracha, Shay||Korzun, Tetiana||Farsad, Khashayar

publication date

  • January 2019