Exogenous lactate increases fat oxidation in resting rats Conference Paper uri icon

abstract

  • BackgroundLactate had been traditionally considered a fatigueassociated byproduct of high intensity exercise. Although several physiological roles of lactate have been revealed in the last decades, its effects on energy metabolism and substrate oxidation remain unknown. Therefore, here, we investigated the effects of lactate on the energy metabolism of resting rats.MethodsMale rats were divided into control (Con; distilled water), caffeine (Caf; 10 mg/kg), lactate (Lac; 4 g/kg), and caffeine plus lactate (Caf+Lac; 10 mg + 4 g/kg) groups. After oral administration of treatments, animals were evaluated for resting energy expenditure, biochemical blood parameters, and mRNA levels of key genes involved in energy metabolism in the soleus muscle.ResultsGroups did not differ in total energy expenditure throughout the 6h posttreatment evaluation. Within the first 4 h, the Lac and Caf+Lac groups showed higher fat oxidation rates than that of the Con group. Carbohydrate oxidation rates were similar between Lac and Con groups. Lactate treatment decreased blood free fattyacid levels and increased the mRNA expression of fatty acid translocase (FAT/CD36) and peroxisome proliferatoractivated receptor gamma coactivator 1alpha (PGC1) in skeletal muscle.ConclusionsOur findings indicate that lactate treatment can enhance fat metabolism in whole body and skeletal muscle.Support or Funding InformationThis paper was supported by the KU Research Professor Program of Konkuk University.

published proceedings

  • FASEB JOURNAL

author list (cited authors)

  • Yoo, C., Kim, J., Kyun, S., Kreider, R., & Lim, K.

citation count

  • 0

complete list of authors

  • Yoo, Choongsung||Kim, Jisu||Kyun, Sunghwan||Kreider, Richard||Lim, Kiwon

publication date

  • April 2020

publisher