FGF/FGFR signaling in health and disease. Academic Article

abstract

• Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR) signaling has crucial roles in a multitude of processes during embryonic development and adult homeostasis by regulating cellular lineage commitment, differentiation, proliferation, and apoptosis of various types of cells. In this review, we provide a comprehensive overview of the current understanding of FGF signaling and its roles in organ development, injury repair, and the pathophysiology of spectrum of diseases, which is a consequence of FGF signaling dysregulation, including cancers and chronic kidney disease (CKD). In this context, the agonists and antagonists for FGF-FGFRs might have therapeutic benefits in multiple systems.

authors

• Feng, Jian

published proceedings

• Signal Transduct Target Ther

altmetric score

• 5.75

author list (cited authors)

• Xie, Y., Su, N., Yang, J., Tan, Q., Huang, S., Jin, M., ... Chen, L.

citation count

• 177

complete list of authors

• Xie, Yangli||Su, Nan||Yang, Jing||Tan, Qiaoyan||Huang, Shuo||Jin, Min||Ni, Zhenhong||Zhang, Bin||Zhang, Dali||Luo, Fengtao||Chen, Hangang||Sun, Xianding||Feng, Jian Q||Qi, Huabing||Chen, Lin

publication date

• September 2020

publisher

• Springer Nature  Publisher

published in

• Signal Transduction and Targeted Therapy  Journal

keywords

• Apoptosis
• Cell Differentiation
• Cell Proliferation
• Embryonic Development
• Fibroblast Growth Factors
• Homeostasis
• Humans
• Neoplasms
• Receptors, Fibroblast Growth Factor
• Signal Transduction

PubMed Central ID

• 32879300

Digital Object Identifier (DOI)

• 10.1038/s41392-020-00222-7

start page

• 181

volume

• 5

issue

• 1

URL

• http://dx.doi.org/10.1038/s41392-020-00222-7

user-defined tag

• 3 Good Health and Well-Being