FGF/FGFR signaling in health and disease Academic Article uri icon

abstract

  • Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR) signaling has crucial roles in a multitude of processes during embryonic development and adult homeostasis by regulating cellular lineage commitment, differentiation, proliferation, and apoptosis of various types of cells. In this review, we provide a comprehensive overview of the current understanding of FGF signaling and its roles in organ development, injury repair, and the pathophysiology of spectrum of diseases, which is a consequence of FGF signaling dysregulation, including cancers and chronic kidney disease (CKD). In this context, the agonists and antagonists for FGF-FGFRs might have therapeutic benefits in multiple systems.

altmetric score

  • 2.85

author list (cited authors)

  • Xie, Y., Su, N., Yang, J., Tan, Q., Huang, S., Jin, M., ... Chen, L.

citation count

  • 16

publication date

  • September 2020