FGF/FGFR signaling in health and disease. Academic Article uri icon


  • Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR) signaling has crucial roles in a multitude of processes during embryonic development and adult homeostasis by regulating cellular lineage commitment, differentiation, proliferation, and apoptosis of various types of cells. In this review, we provide a comprehensive overview of the current understanding of FGF signaling and its roles in organ development, injury repair, and the pathophysiology of spectrum of diseases, which is a consequence of FGF signaling dysregulation, including cancers and chronic kidney disease (CKD). In this context, the agonists and antagonists for FGF-FGFRs might have therapeutic benefits in multiple systems.

published proceedings

  • Signal Transduct Target Ther

altmetric score

  • 5.75

author list (cited authors)

  • Xie, Y., Su, N., Yang, J., Tan, Q., Huang, S., Jin, M., ... Chen, L.

citation count

  • 177

complete list of authors

  • Xie, Yangli||Su, Nan||Yang, Jing||Tan, Qiaoyan||Huang, Shuo||Jin, Min||Ni, Zhenhong||Zhang, Bin||Zhang, Dali||Luo, Fengtao||Chen, Hangang||Sun, Xianding||Feng, Jian Q||Qi, Huabing||Chen, Lin

publication date

  • September 2020