Application of Whole-Genome Sequencing to an Unusual Outbreak of Invasive Group A Streptococcal Disease
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Whole-genome analysis was applied to investigate atypical point-source transmission of 2 invasive group A streptococcal (GAS) infections. Isolates were serotype M4, ST39, and genetically indistinguishable. Comparison with MGAS10750 revealed nonsynonymous polymorphisms in ropB and increased speB transcription. This study demonstrates the usefulness of whole-genome analyses for GAS outbreaks.
author list (cited authors)
Galloway-Peña, J., Clement, M. E., Sharma Kuinkel, B. K., Ruffin, F., Flores, A. R., Levinson, H., ... Fowler, V. G.